FSN 132 Chapter 12: Chapter 12 Precursors of the Renaissance Memorization Slides/Study Guide
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Cystic Fibrosis is an autosomal recessive disease which usually leads to death in the early to mid-20s. Carriers are not affected. The normal allele is F and the disease allele is f. You want to know how strong selection is against the disease allele, and set out to find its selection coefficient (s).
What are the relative fitness of the normal genotypes? (0.5 pt. each, no calculation needed)
ÏFF =
ÏFf =
You find the following data regarding the number of people affected by CF 30 years ago, and today, from genetic tests of US hospital patients. In both years, the sample size was of 1348 individuals chosen at random from the population. It is known that that the mean relative fitness of the 1987 population was 0.919.
Distribution | FF | Ff | ff |
1987 | 661 | 566 | 121 |
2018 | 782 | 489 | 77 |
find the relative fitness of the disease genotype, and the selection coefficient of the disease allele. Show your work and round results to 2 significant figures :
A, B, and C are partners and sharing profits 2/5thand 1/5th respectively. The balance sheet on31st December, 2008, is as follows:-
Liabilities | Rs | Assets | Rs |
Creditors | 29000 | Cash at Bank | 4000 |
Capital-A | 30000 | Debtors | 30000 |
Capital-B | 20000 | Stock | 45000 |
Capital-C | 20000 | Plant & Fixtures | 20000 |
Total | 99000 | Total | 99000 |
âCâ dies on1st September, 2009 and the deed provides that theestate of the deceased shall be entitled to a share of the profitsup to the date of death based on the profits of the previous year,together with a share in repect of goodwill to be calculated on thebasis of two years purchase of the average net profits of theprevious three years. The net profits for the years 2006, 2007 and2008 were Rs20,000, Rs22000 and Rs18000 respectively. Six percentinterest was agreed to be credited on the capital of each partner.C has withdrawn Rs1500 from the date of the last balance sheet tothe date of his death. The whole amount due to the deceased as at1st September, 2009 was to be temporarily credited tohis loan account opened in the name of the Executors. Show detailworking and the amount to be credited.