BPK 205 Chapter Notes -Anterior Pituitary, Pregnenolone, Lipophilicity

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Practice questions chapter 7: briefly describe the steps in the synthesis, storage and release of a peptide hormone. [ ~ a page, 15 minutes: synthesis, always synthesized from cholesterol, mitochondria converts cholesterol to pregnenolone, smooth endoplasmic reticulum converts pregnenolone to hormone testosterone, progesterone, and estrogen in gonads. Aldosterone, and cortisol in adrenal cortex: storage, circulated, lipophilic so cannot be stored in vesicles, stored as precursors in cytoplasm of endocrine cells, transported bound to carrier proteins (extends their half-life, will either: Enter a cell and bind to dna in the nucleus to turn on or off a gene (turning on a gene can lead to a slow protein synthesis) Provide the names of associated hypothalamic releasing factors where applicable. [1 figure + at least one page of clear writing]. Anterior pituitary: neurons in parvocellular region of hypothalamus synthesize and release. Releasing hormones among capillary plexuses: portal blood system carries releasing hormones to anterior hypophysis (pituitary).

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