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BPK 205 Chapter Notes -Hypovolemia, Vasoconstriction, Baroreceptor

Biomedical Physio & Kines
Course Code
BPK 205
Parveen Bawa

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1. Using the blood pressure regulation ‘flow chart’, indicate at what points
(variables) various pharmacological agents act to treat high blood pressure.
2. Describe how the body adapts physiologically to hypovolemia. Explain the
consequences of losing > 30% blood volume.
a. 10 % blood loss
i. Initial result:
1. reduction of BV, SV, Q, BP, TPR
ii. Response: (baroreceptors sense loss in BP)
1. Q:
a. SNS Beta adrenergic stimulation HR + SV
b. SNS Alpha adrenergic vasoconstriction
increase Resistance and BP
c. Q returns to normal after
2. HR
a. Slightly higher HR because SV did not completely
recover back to normal level (needed for Q to
recover to normal)
3. TPR:
a. Vasodilation at vital organs
b. Vasoconstriction at non-vital organs
c. After initial TPR increase, the TPR returns to
normal within 15 min
b. >30% blood loss
i. Physiological changes
ii. Blood flow to non vital organs significantly reduced
iii. Blood flow concentrated towards vital organs (Brain, Heart)
3. Outline the changes that occur in HR, SV, and arterial pressure during an acute
bout of exercise.
a. HR
i. SNS Beta adrenergic stimulation HR (linear increase)
ii. Decreased PNS, none over 130 bpm
b. SV
i. SNS [Ca[ contractility increases SV ~30%
ii. Greater emptying not filling
c. Arterial Pressure
i. Increase Q increased BP
ii. Despite Decreased TPR
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