Published on 13 Mar 2011
School
Department
Course
Chapter 9 Measles
History:
·origin is unknown, Rhazes (900AD)
thought they came from same cause
·Prevailing theor y: red rash represented the mother’s menstrual blood that
accumulates in womb
·disease was welcomed “for children to rid of the s o-called poison”
Symptoms:
·fever and the 3 Cs (coryza, cough, conjunctivitis)
·photophobia
·Koplik’s spots, sore throat
·rash (face, neck), lesions (trunk, extremities)
Transmission:
·droplets and direct contact (from 4 days before until 4 days after rash appears)
·highly contagious, human are only host, dependent on a human reservoir
Treatment:
·good hydration, good nutrition
·vitamin A
·antibiotics
·Quarantine
Vaccine:
·lifelong immunity from previous infections
·infants protected if mother had measles during pregnancy
·weakened (attenuated) virus as effective vaccine vaccine
·combination with mumps and rubella (MMP)
·vaccine is both heat and light sensitive
·2 doses of the vaccine
Genu
s: paramyxovirusgroup of viruses contain RNA, infects respiratory epithelium
Thomas Sydenhams
·fist to clearly separate measles from small pox
·recognized complications: cancrum oris and encephalitis
Francis Home:
·demonstrated the infective nature of measles, can be transmission by blood
Panum:
·geographic location ideal for epidemiological study: isolated islands
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Document Summary

Origin is unknown, rhazes (900ad)(cid:0) thought they came from same cause. Prevailing theory: red rash represented the mother"s menstrual blood that accumulates in womb. Disease was welcomed for children to rid of the so-called poison . Fever and the 3 cs (coryza, cough, conjunctivitis) Droplets and direct contact (from 4 days before until 4 days after rash appears) Highly contagious, human are only host, dependent on a human reservoir. Infants protected if mother had measles during pregnancy. Genus: paramyxovirus(cid:0) group of viruses contain rna, infects respiratory epithelium. Fist to clearly separate measles from small pox. Demonstrated the infective nature of measles, can be transmission by blood. Geographic location ideal for epidemiological study: isolated islands www. notesolution. com. 1963 enders: able to grow virus and produce effective vaccine. 1969: discovery of relationship of measles and rare degenerative disease in nervous system of children called subacute sclerosing panencephalitis. Prodrome stage (day 0): fever, 3c"s, photophobia, symptoms increase in severity.

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