MIMM 214 Lecture Notes - Lecture 7: Interferon, Co-Stimulation, Cell Membrane
4 Feb 2017
School
Department
Course
Professor
Document Summary
Molecular patterns that are unique to microorganisms expressed in different categories of microorganisms. Pathogens have specific molecular patterns that style = pathogen-associated. Patterns (pamps) and are widely support their life. Pamps are recognized by pattern recognition receptors (prrs) on host cells. Molecules found on microbe surface: peptidoglycan (pgn) and pgn-embedded molecules (lta) on the cell wall of gram-positive bacteria, endotoxin (lps) on the cell wall of gram-negative bacteria, flagellin on bacteria with flagella. Nucleic acid patterns: dsrna in viruses some viruses when they replicate will produce dsrna, ssrna in viruses, unmethylated cpg in bacteria and herpes viruses. Cpg motifs are often methylated in host cells. Host cells have nucleic acids but there are certain types of nucleic acid structures that are unique to microorganisms. These are common patterns expressed by many microorganisms; not specific to a given pathogen. Receptors in host cells that recognize pamps. Located at different sites depending on the pamp they recognize: cell surface, secreted.
