MIMM 214 Lecture Notes - Lecture 5: Irak1, Rig-I, Myd88
5 Jan 2019
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Involves the activation of 2 signalling pathways: Transcription factor, activated upon signalling from prrs. Goes into the nucleus to initiate transcription of all the genes that have the nfkb elements. Activates a whole transcriptional program that determines transcription. Myd88 / mal / trif / tram / Want to understand how these cascades link with different responses, in some it is pro-inflammatory but in some other cells it may put in motion another transcription program. Nod proteins are prrs that are intracellular and reside in the cytoplasm in an inactive form. Will recognize peptidoglycan and acts as a gram+ pump inside cell. Nod will dimerize upon binding to bacteria ligand derived from peptidoglycan, bind to a kinase that will activate nfkb signalling cascade. Rig-i proteins use viral nucleic acids as ligand. Dimerization, recruit and activate molecules that then activate. Il-1, il-6, tnf- , and il-12 for th1 response. These are the ones secreted for viral infections.
