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Lecture 8

Lecture 8

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Department
Biology
Course
BIO120H1
Professor
Darrel Desveaux
Semester
Winter

Description
Lecture 8 Intracellular Vesicular Transport Part 2: Sorting and Packaging in the Golgi Cargo From ER to Cis Golgi Network o Cargo packaged in COPII-coated vesicles Bud from ER exit sites o Cargo signals? Exit signal Bound by cargo receptors Other cargo have no exit signal, but are packaged because of [high] in ER o COPII-coated vesicles bud from ER exit site Shed COPII coat (mature vesicle) Fuse with each other to form vesicular tubular clusters o Vesicular tubular clusters move to Golgi apparatus by microtubules Retrieval (Retrograde) Transport o Retrieval transport: COPI-coated vesicles Vesicles from vesicular tubular clusters and Golgi to ER o Vesicles contain: Escaped ER resident protei
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