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Biology
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23 Jan 2018

What is a point mutation?

A. The movement of a gene from one location to another in the chromosome
B. A single base pair change
C. Deletion of a gene
D. Rearrangement of the gene order within a chromosome
E. Movement of a gene between different species

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Deanna Hettinger
Deanna HettingerLv2
25 Jan 2018
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Related questions

a. Which DNA mutation is more likely to have a detrimental effect on the protein it codes for: a 1 base pair deletion from the middle of the coding sequence of a gene, or a 9-base pair deletion from the same region of the gene? Explain why?

b. Would the outcome be different if the deletions happened within the gene’s intron? Explain why?

Prader-Willi is a human syndrome that develops in individuals who are homozygous null for expression of the SNRPN gene. The SNRPN gene is located on the q arm of chromosome 15 region 11-13 (15q11-q13), and is normally maternally imprinted. Which of the following individuals will have Prader-Willi Syndrome (CHOOSE ALL THAT APPLY). a) An individual with a wild type maternal chromosome 15 and a paternal chromosome 15 with a deletion of the q11-q13 region. b) An individual with a wild type paternal chromosome 15 and a nonsense mutation in the maternally inherited SNRPN gene. c) An individual with a wild type paternal chromosome 15 and a maternal chromosome 15 with a deletion of the q11-q13 region. d) An individual whose mother was homozygous null for the SNRPN gene sequence and whose father was homozygous wild type for the SNRPN gene sequence. e) An individual with increased DNA methylation of the promoter of the SNRPN gene on the paternally inherited SNRPN allele and a wildtype maternally inherited allele of SNRPN

What is more likely to have a detrimental effect on the phenotype: a 3 base pair deletion from the middle of the coding sequence of a gene, or a 8 base pair deletion from the same region of the gene? Why? Would the outcome be different if the deletions happened within the gene’s intron? Why?

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