Renal functions test include all the followings EXCEPT
i) Excretion of biles
ii) Excretion of metabolic waste and by-products 
iii) Endocrine function 
iv) Regulation of plasma electrolytes, fluid/water balance, blood pressure

E4.13 Pharmacokinetics of an Oral Dose Model. Write the ODEs for the five-compartment human thyroxine kinetics model shown in Fig. 4.34, where the first two compartments 200 Dynamic Systems Biology Modeling and Simulation ABSORPTI ks Qs 9p ORAL INPUT ka DISSOLUTION2 EXCRETION THYROXINE DISTRIBUTION & METABOLISM Fig. 4.34 Thyroxine distribution model following an oral dose input. represent dissolution, absorption and fecal excretion of an oral dose input of thyroxine and the other compartments represent the distribution and elimination of thyroxine Parameter values ks, . . ., k9-1.35, 1.03, 0.14, 0.0548, 0.0046, 0.00208 (DiStefano III Wilson et al. 1975; DiStefano III and Mak 1979). Simulate the whole model for both an oral dose D of T. Use the following oral T-dose parameters: k-1.3, k2-0.62, and k- 0.62. Units for all ks are 1/h. Note: If dissolution of the drug is very fast relative to absorption and excretion from gut, a single compartment is often used to represent an oral input pathway to blood.