Randomized controlled trials (RCTs) are the strongest research design for establishing cause and effect. Which of the following is the main limitation of RCTs?
a) RCTs may not be ethical for some studies.
b) RCT design cannot control for confounders.
c) Randomized controlled trials may have a disproportionate number of people exposed to the risk factor.
d) Randomized controlled trials are, by their very design, likely to be very biased towards an expected outcome.

Question

Randomized controlled trials (RCTs) are the strongest research design for establishing cause and effect. Which of the following is the main limitation of RCTs?
a) RCTs may not be ethical for some studies.
b) RCT design cannot control for confounders.
c) Randomized controlled trials may have a disproportionate number of people exposed to the risk factor.
d) Randomized controlled trials are, by their very design, likely to be very biased towards an expected outcome.

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