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Class Notes for PCOL3012 at University of Sydney

Drug Design and Development

PCOL3012 Lecture Notes - Lecture 9: Naloxone, Fentanyl, Remifentanil

Drug Design and Development Lecture 9 Quantitative structure activity relationships- Opioids Opioids-Opium-Morphine Opioid: any substance (endogenous or synthetic) that produces morphine like effects Opium:...

Pharmacology
PCOL3012
Rachel
PCOL3012 Lecture Notes - Lecture 12: Nuclear Membrane, Esterase, Alkylation

Polynucleotides as drug targets: cisplatin (case study) Lecture 12 Structure of DNA: DNA as a drug target: DNA has features that make it amenable as a drug target. Macroscopic to...

Pharmacology
PCOL3012
Rachel
PCOL3012 Lecture Notes - Lecture 5: Thioether, Alpha Helix, Hydrogen Bond

Structure of drug targets: Proteins Transporter, receptors and enzymes Amino acids Proteins Structure Majority of drug targets are proteins: 1. Receptors 2. Enzymes 3. Transporters ...

Pharmacology
PCOL3012
Rachel
PCOL3012 Lecture Notes - Lecture 6: Glucose Transporter, Glutamate Transporter, Succinic Acid

Receptors (and transporters) as Drug Targets Cellular locations of Drug Targets Cell surface targets: Transporters Receptors Ion channels Intracellular targets: Enzymes Nuclear receptors...

Pharmacology
PCOL3012
Rachel
PCOL3012 Lecture Notes - Lecture 7: Isothermal Titration Calorimetry, Imidazole, Histidine

Cellular and molecular techniques in neuropharmacology Recombinant Protein expression: Amino acid sequence alignment: Introduce mutation: Introduce a single point mutation and investigate func...

Pharmacology
PCOL3012
Rachel
PCOL3012 Lecture Notes - Lecture 4: Hydrolysis, Refractive Index, Molar Refractivity

QSAR: Other physiochemical parameters Electronic substituent Constant The electronic substituent parameter is defined as , described by Hammett Otherwise, is known as the Hammett parameter. An...

Pharmacology
PCOL3012
Rachel
PCOL3012 Lecture Notes - Lecture 8: Nasal Administration, Neuraminidase Inhibitor, Influenzavirus B

Drug Design and development Lecture 8 Proteins as drug targets: Antivirals Approximately, 1500 Australians die per year from Flu World-wide, Flu affects up to 500 million people per year Influenza: Viral ...

Pharmacology
PCOL3012
Rachel
PCOL3012 Lecture Notes - Lecture 3: Hydrogen Bond, Biphenyl, Regression Analysis

Lecture 3 QSAR (Quantitative structure activity relationships) Designing Drugs Pharmacophore Is the ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a spec...

Pharmacology
PCOL3012
Rachel
PCOL3012 Lecture Notes - Lecture 14: Pyridoxine, Coordinate Covalent Bond, Pentetic Acid

Chelatin Therapy Lecture 14 Lecture outline: 1. Heavy metal poisoning 2. How chelatin therapy works 3. Chelating agents in use 4. Endogenous chelators Toxic Metals: Metals and derivatives are discharged into the environmen...

Pharmacology
PCOL3012
Rachel
PCOL3012 Lecture Notes - Lecture 2: Medicinal Chemistry, Molecular Geometry, Drug Design

Drug design and development Lecture 2 Fluorine common halogen used in drugs It is extremely electonegative Can change the way the drug partitions into water soluble or fatsoluble matrices Most drugs are organic (based arou...

Pharmacology
PCOL3012
Rachel

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