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Class Notes for GENE30001 at University of Melbourne

Evolutionary Genetics and Genomics

GENE30001 Lecture Notes - Lecture 7: Linkage Disequilibrium, Selective Sweep, Haplotype

Lecture 7 and 8 Measures of Nucleotide Diversity Wednesday, 22 June 2016 4:23 PM Here we can see that each highlighted column has at least 1 allele with variation on a site. BECAUSE IT IS TOO HARD TO COMPARE ALL OF THEM, n...

Genetics
GENE30001
Charles Robin
GENE30001 Lecture Notes - Lecture 5: Gene Duplication, Concerted Evolution, Sister Chromatids

Lecture 5: dNdS Positive Selection and Gene Duplication Wednesday, 22 June 2016 1:50 PM dN = changes per nonsynonymous sites dS= changes per synonymous site THESE DONT EQUAL EACH OTHER. 000 002 002 004 000 002 004 003 003 ...

Genetics
GENE30001
Charles Robin
GENE30001 Lecture Notes - Lecture 6: Mutation Rate, Genetic Drift, Gametogenesis

Lecture 6: dNdS continued and McDonald Kreitman Test Wednesday, 22 June 2016 3:57 PM The MK test is a test of the neutral model of DNA sequence divergence between two species (McDonald MK McDonald Kreitman Test: As mentio...

Genetics
GENE30001
Charles Robin
GENE30001 Lecture Notes - Lecture 3: Lac Repressor, Tetraodontidae, Deoxyribonuclease I

Lecture 3 : Negative Selection and selective constraint Wednesday, 22 June 20111:58 AM ENCODE: Incorrectly overinterpreted biochemical function DNAse1 Footprinting. DNAse1 cant to a short fragment due to an added protein, ...

Genetics
GENE30001
Charles Robin
GENE30001 Lecture Notes - Lecture 2: Mutation Rate, Pypy, Pseudogene

Lecture 2 Mutations and Mutation Rates Wednesday, 22 June 10:51 AM Definitions: Polymorphisms: Human genetics >1 (SNPs vs SNV) frequency is too high to be explained by mutation alone Neutralist theory: Most molecular varia...

Genetics
GENE30001
Charles Robin
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