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PHRM4011 (12)

Class Notes for PHRM4011 at University of Queensland

Integrated Patient Centred Care 1

PHRM4011 Lecture Notes - Lecture 12: Diabetic Nephropathy, Pharmacodynamics, Osteoporosis
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Natural progression Cell death and organ failure are well known effects of aging However ageing alone doesnt explain full story of degenerative disease E.g parkinsons loss of DA receptors Degenerative disease Characterised...

Pharmacy
PHRM4011
Dr Stephanie Hennig
PHRM4011 Lecture Notes - Lecture 11: Hepatotoxicity, Azo Compound, Rheumatoid Arthritis
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Rheumatoid arthritis Chronic inflammation of joints (results in degradation after awhile) with unknown cause o More severe have extraarticular (out of joint) symptoms in heart, lungs, etc o Starts at age 2555 o Most commo...

Pharmacy
PHRM4011
Dr Stephanie Hennig
PHRM4011 Lecture Notes - Lecture 7: Bioavailability, Trough Level
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Pharmacokinetic principles guide the selection of dose, dosing rates, dosing intervals, dosage forms, and routes of administration in therapeutics Clearance CL describes elimination processes, thus .... CL is used to setr...

Pharmacy
PHRM4011
Dr Stephanie Hennig
PHRM4011 Lecture Notes - Lecture 3: Oxazepam, Postmarketing Surveillance, Digoxin
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Digoxin Serum target for HF 0.50.8mcgL, AF 0.52mcgL no mortality benefit For CrCl60mLmin halve dose o CrCl3060mLmin 62.5mcg250 o CrCl1030 62.5125 o CrCl<10 62.5 d or alternate days Monitor trough level (min 6hr post dos...

Pharmacy
PHRM4011
Dr Stephanie Hennig
PHRM4011 Lecture Notes - Lecture 8: Diminishing Returns, Theophylline, Bronchus
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PKPD PKPD is not just PK and PD put together where PK provides an exposure measure and PD provides the exposure response o PK provides the time course and PD provides the exposure response and together you get the time cou...

Pharmacy
PHRM4011
Dr Stephanie Hennig
PHRM4011 Lecture Notes - Lecture 10: Estrogen, Pelvic Inflammatory Disease, Sciatica
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Dysmenorrhoea (period pain) Experienced by 70 of women o Loss of productivity from workschool o Onset at 12, the earlier the onset the higher chance of pain o Lasts 37 days Caused by progesterone controlling prostaglandi...

Pharmacy
PHRM4011
Dr Stephanie Hennig
PHRM4011 Lecture Notes - Lecture 5: Bisphosphonate, Edema, Adrenal Insufficiency
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Ceasing statins o Benefits: secondary benefits for CVD o Harm: SE myalgia, rhabdomyolysis, fatigue o Reduce dose OR Cease if px has limited life expectancylow CVD risk stop immediately Ceasing benzos o Benefits: modest s...

Pharmacy
PHRM4011
Dr Stephanie Hennig
PHRM4011 Lecture Notes - Lecture 6: Hyponatremia, Creatinine, Urobilinogen
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Liver Liver function tests (also called LFTs) are blood tests that can provide information about how your liveris working. test the levels of a number of proteins and enzymes that are either o produced by liver cells o r...

Pharmacy
PHRM4011
Dr Stephanie Hennig
PHRM4011 Lecture Notes - Lecture 9: Medication Therapy Management
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Confidentiality of HMRRMMR All info is confidential GP the approved service provider (community pharmacy or accredited pharmacist) will hold a copy of the report. must keep a copy of every completed HMR report for a period...

Pharmacy
PHRM4011
Dr Stephanie Hennig
PHRM4011 Lecture Notes - Lecture 4: Allopurinol, Digoxin, Nonsteroidal Anti-Inflammatory Drug
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Polypharmacy: define, describe prevalencedriversharm, why older people at higher risk of harm, evidence for harm of these medications, recommend tools, common meds taking 5 or more medsmore meds than indicatedmost importa...

Pharmacy
PHRM4011
Dr Stephanie Hennig
PHRM4011 Lecture Notes - Lecture 1: Nortriptyline, Omeprazole, Adverse Drug Reaction
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Prolong life Cholesterol lowering drugs in cardiovascular disease One metaanalysis of 17,617 patients found that the reduction in the risk of major coronary events (30), cardiovascular mortality (27), and allcause mortalit...

Pharmacy
PHRM4011
Dr Stephanie Hennig
PHRM4011 Lecture Notes - Lecture 2: Asthma, Streptomycin, Heart Failure
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Digoxinamiodarone avoid as 1 line for AF PPIs bone loss and increased fractures B12 deficiency Thiazides exacerbate gout NSAID selective vs nonselective vs paracetamol same efficacy for OA High GI risk PPI + Naproxen...

Pharmacy
PHRM4011
Dr Stephanie Hennig

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